Yes, in 2022 stock markets in The United States are open on the day before Thanksgiving, Wednesday, November 23.
The Stock Market is Open the day before Thanksgiving, Wednesday, November 23rd. This day is not considered a holiday, however many take the day off to travel or see family. The stock market will be open with normal trading hours on this day.
Source 1 - https://www.nyse.com/markets/hours-calendars