No, The Stock Markets in The United States are closed on Thanksgiving, Thursday, November 23, 2022
Thanksgiving always falls on the 4th Thursday of November. It is a US federal holiday. Many entities are closed on Thanksgiving day, include the The US Stock Markets. They will be closed on Thanksgiving Day. The following day, Friday, the stock market will be open. Please note, that on this Friday the stock market will have reduced hours and close at 1pm Eastern Standard Time. Happy Thanksgiving!
Source 1 - https://www.nyse.com/markets/hours-calendars